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| Player | Team | IP | ER | BB | H | IR/Scored | Strikeouts | ERA |
|---|---|---|---|---|---|---|---|---|
| Tarik Skubal | Athletics | 15.33 | 0 | 5 | 0 | 0 / 0 | 20 | 0.00 |
| Paul Skenes | Pittsburgh | 14.33 | 1 | 12 | 3 | 0 / 0 | 20 | 0.63 |
| Logan Webb | San Francisco | 13.00 | 1 | 12 | 2 | 0 / 0 | 18 | 0.69 |
| Pablo López | Minnesota | 14.33 | 3 | 7 | 1 | 0 / 0 | 14 | 1.88 |
| Hogan Harris | Tampa Bay | 9.33 | 1 | 7 | 3 | 3 / 0 | 12 | 0.96 |
| Randy Rodríguez | San Francisco | 6.00 | 0 | 5 | 0 | 3 / 1 | 10 | 0.00 |
| Aroldis Chapman | Boston | 5.67 | 0 | 1 | 0 | 3 / 0 | 8 | 0.00 |
| Carlos Rodón | New York (NYY) | 7.00 | 1 | 2 | 1 | 0 / 0 | 10 | 1.29 |
| Joey Cantillo | Cleveland | 7.00 | 1 | 4 | 4 | 0 / 0 | 13 | 1.29 |
| Garrett Cleavinger | Tampa Bay | 6.00 | 0 | 0 | 2 | 2 / 0 | 8 | 0.00 |
| Justin Verlander | San Francisco | 12.00 | 3 | 10 | 3 | 0 / 0 | 14 | 2.25 |
| Yoshinobu Yamamoto | Los Angeles | 12.33 | 4 | 8 | 3 | 0 / 0 | 14 | 2.92 |